Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19030708 | 0.74 | IRAK4 (0.47) | — | |
| SCHEMBL18230019 | 0.62 | CYP2E1 (0.50) | — | |
| SCHEMBL25313829 | 0.61 | TDP1 (0.46) | — | |
| SCHEMBL17476765 | 0.60 | MAPT (0.58) | PGR | |
| SCHEMBL2672411 | 0.59 | ALDH1A1 (0.56) | — | |
| SCHEMBL31308695 | 0.58 | XDH (0.43) | — | |
| SCHEMBL3782420 | 0.58 | MAPK8 (0.44) | — | |
| SCHEMBL22634571 | 0.58 | CYP2C9 (0.44) | — | |
| SCHEMBL29397913 | 0.58 | CYP2C9 (0.44) | — | |
| SCHEMBL16891571 | 0.57 | CYP2C19 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017108723-A2 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-29 | — | — | WO | disclosed |