Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 8/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19032808 | 0.91 | CFTR (0.75) | CFTRMEN1KMT2AMAPK1MAPT | |
| SCHEMBL19046547 | 0.87 | CFTR (0.69) | CFTRMEN1KMT2AMAPK1MAPT | |
| SCHEMBL19046530 | 0.85 | CFTR (0.67) | CFTRMEN1KMT2AMAPK1MAPT | |
| SCHEMBL19046554 | 0.80 | CFTR (0.65) | CFTRMEN1KMT2AMAPK1MAPT | |
| SCHEMBL19046533 | 0.80 | CFTR (0.55) | CFTRMEN1KMT2AMAPK1MAPT | |
| SCHEMBL19046529 | 0.80 | CFTR (0.55) | CFTRMEN1KMT2AMAPK1MAPT | |
| SCHEMBL19046406 | 0.77 | CFTR (0.66) | CFTRKMT2AHTTALDH1A1 | |
| SCHEMBL19046548 | 0.77 | CFTR (0.85) | CFTRMEN1KMT2AMAPK1MAPT | |
| SCHEMBL19046538 | 0.77 | CFTR (0.65) | CFTRALDH1A1 | |
| SCHEMBL29478065 | 0.76 | CFTR (1.00) | CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4071140-B1 | CFTR REGULATORS AND METHODS OF USE THEREOF | UNIV CALIFORNIA (US) | 2024-07-03 | — | — | EP | disclosed |
| EP-4071140-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | The Regents of The University of California (US) | 2022-10-12 | — | — | EP | disclosed |
| WO-2017112950-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-29 | — | — | WO | disclosed |