Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 3/20 | 0.65 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.65 |
| ▸ | FYN | P06241 | 16/20 | 0.63 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.51 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18861136 | 0.89 | CHEK1 (0.55) | CHEK2CHEK1FYNTGFBR1ACVR1 | |
| SCHEMBL19048389 | 0.87 | CHEK1 (0.53) | CHEK2CHEK1FYNTGFBR1 | |
| SCHEMBL18860437 | 0.85 | FYN (0.69) | CHEK2CHEK1FYNTGFBR1ACVR1 | |
| SCHEMBL29576661 | 0.82 | FYN (0.76) | CHEK2CHEK1FYNTGFBR1ACVR1 | |
| SCHEMBL15334401 | 0.82 | FYN (0.76) | CHEK2CHEK1FYNTGFBR1ACVR1 | |
| SCHEMBL18861243 | 0.82 | AXL (0.60) | — | |
| SCHEMBL21185638 | 0.80 | CHEK2 (0.58) | CHEK2CHEK1FYN | |
| SCHEMBL30521707 | 0.78 | FYN (1.00) | CHEK2CHEK1FYNTGFBR1 | |
| SCHEMBL18613347 | 0.78 | FYN (1.00) | CHEK2CHEK1FYNTGFBR1 | |
| SCHEMBL23158630 | 0.76 | CHEK2 (0.61) | CHEK2CHEK1FYNTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10442797-B2 | Pyridone derivatives having tetrahydropyranylmethyl groups | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-10-15 | — | — | US | disclosed |
| US-20170183329-A1 | PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYLMETHYL GROUP | DAIICHI SANKYO CO LTD (JP) | 2017-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10442797-B2 | Pyridone derivatives having tetrahydropyranylmethyl groups | AXL, TYRO3, PDXK | CHEK2 330/4885CHEK1 838/4885FYN 7/4885 |
| US-20170183329-A1 | PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYLMETHYL GROUP | AXL, TYRO3, PDXK | CHEK2 337/4885CHEK1 857/4885FYN 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.