Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 3/20 | 0.31 |
| ▸ | AKT2 | P31751 | 3/20 | 0.31 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1907310 | 0.87 | KDM4E (0.31) | EGFRKDM4EALDH1A1HPGDUBE2N | |
| SCHEMBL1907305 | 0.83 | AKT1 (0.34) | AKT1AKT2 | |
| SCHEMBL1908428 | 0.82 | MERTK (0.35) | EGFRKDM4EALDH1A1HPGDUBE2N | |
| SCHEMBL1898953 | 0.81 | AKT1 (0.37) | KDM4EALDH1A1AKT1 | |
| SCHEMBL1900820 | 0.80 | MERTK (0.34) | EGFRKDM4EALDH1A1HPGDUBE2N | |
| SCHEMBL1903295 | 0.80 | EGFR (0.38) | EGFRKDM4EALDH1A1HPGDUBE2N | |
| SCHEMBL14118861 | 0.80 | AKT1 (0.44) | EGFRKDM4EALDH1A1HPGDUBE2N | |
| SCHEMBL1907601 | 0.79 | — | — | |
| SCHEMBL1907828 | 0.79 | AKT1 (0.37) | AKT1 | |
| SCHEMBL1905736 | 0.79 | MEN1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011055115-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2011-05-12 | — | — | WO | disclosed |