Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | UBE2N | P61088 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 3/20 | 0.31 |
| ▸ | AKT2 | P31751 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1907601 | 0.88 | — | — | |
| SCHEMBL1905018 | 0.87 | EGFR (0.34) | KDM4ELMNAUSP2GBA1TSHR | |
| SCHEMBL1534849 | 0.82 | MAPK14 (0.34) | KDM4EHPGDSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL1902949 | 0.81 | AKT1 (0.36) | ALDH1A1AKT1MAPTNPSR1KDR | |
| SCHEMBL1907828 | 0.80 | AKT1 (0.37) | AKT1 | |
| SCHEMBL1907209 | 0.80 | SCN9A (0.36) | KDM4ELMNAUSP2GBA1TSHR | |
| SCHEMBL1907254 | 0.80 | AKT1 (0.43) | LMNAALDH1A1AKT1AKT2MTNR1A | |
| SCHEMBL1905911 | 0.79 | ALDH1A1 (0.33) | KDM4ELMNAUSP2GBA1TSHR | |
| SCHEMBL1902760 | 0.79 | AKT1 (0.47) | AKT1AKT2 | |
| SCHEMBL1903889 | 0.79 | KDM4E (0.30) | KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011055115-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2011-05-12 | — | — | WO | disclosed |