Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | UBE2N | P61088 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 3/20 | 0.32 |
| ▸ | AKT2 | P31751 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.31 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1900820 | 0.88 | MERTK (0.34) | MERTKEGFRALDH1A1KDM4EHPGD | |
| SCHEMBL1901153 | 0.87 | LCK (0.35) | MERTKEGFRALDH1A1KDM4EHPGD | |
| SCHEMBL1898806 | 0.86 | HSD17B10 (0.39) | EGFRALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL1900099 | 0.85 | LCK (0.35) | MERTKEGFRKDRTNK2LCK | |
| SCHEMBL1905018 | 0.82 | EGFR (0.34) | MERTKEGFRALDH1A1KDM4EHPGD | |
| SCHEMBL1900571 | 0.80 | EGFR (0.38) | MERTKEGFRALDH1A1KDM4EHPGD | |
| SCHEMBL1902664 | 0.80 | AKT1 (0.45) | ALDH1A1KDM4EHPGDUBE2NSMN1; SMN2 | |
| SCHEMBL1907310 | 0.78 | KDM4E (0.31) | EGFRALDH1A1KDM4EHPGDUBE2N | |
| SCHEMBL1905294 | 0.77 | AKT1 (0.32) | MERTKTNK2LCKAKT1CHEK1 | |
| SCHEMBL1902949 | 0.77 | AKT1 (0.36) | MERTKEGFRALDH1A1KDRTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011055115-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2011-05-12 | — | — | WO | disclosed |