Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.59 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 3/20 | 0.42 |
| ▸ | DRD5 | P21918 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2365603 | 0.82 | ESR1 (0.59) | ESR1ESR2ABHD6KDM4ELMNA | |
| SCHEMBL13846949 | 0.81 | GRIN2C (0.53) | MTNR1BDRD1DRD5DRD2DRD3 | |
| SCHEMBL6631355 | 0.80 | MTNR1B (0.46) | ESR1ESR2LMNAMTNR1BHTT | |
| SCHEMBL2309023 | 0.79 | ESR1 (0.85) | ESR1ESR2ABHD6HDAC1HDAC6 | |
| SCHEMBL18408493 | 0.78 | MTNR1B (0.44) | MTNR1BDRD1DRD5DRD2DRD3 | |
| SCHEMBL30878525 | 0.76 | ESR1 (0.57) | ESR1ESR2KDM4ELMNAALDH1A1 | |
| SCHEMBL30878562 | 0.76 | ESR1 (0.57) | ESR1ESR2KDM4ELMNAALDH1A1 | |
| SCHEMBL25722286 | 0.76 | ESR1 (0.57) | ESR1ESR2KDM4ELMNAALDH1A1 | |
| SCHEMBL1904807 | 0.75 | ESR1 (0.50) | ESR1ESR2MAPTDRD2DRD4 | |
| SCHEMBL3895230 | 0.74 | ESR1 (1.00) | ESR1ESR2ABHD6HDAC6DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322162-A1 | 5HT2C receptor modulator compositions and methods of use | Arena Pharmaceuticals, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |