Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1905475 | 0.80 | ESR1 (0.59) | MTNR1BMTNR1AKMT2ALMNAESR1 | |
| SCHEMBL16417004 | 0.76 | ESR1 (0.62) | KMT2AMEN1ESR1ESR2GAA | |
| SCHEMBL1096119 | 0.73 | HTR2C (0.50) | MTNR1BMTNR1AKMT2AMEN1LMNA | |
| SCHEMBL6635416 | 0.73 | MTNR1B (0.38) | MTNR1BMTNR1AKMT2AMEN1LMNA | |
| SCHEMBL6631057 | 0.72 | HTR2A (0.45) | MTNR1BMTNR1AKMT2AMEN1LMNA | |
| SCHEMBL1095709 | 0.69 | HTR2C (0.43) | MTNR1BMTNR1AKMT2AHTR2AHTR2C | |
| SCHEMBL4936397 | 0.69 | HTR2C (0.48) | MTNR1BMTNR1AKMT2ALMNAHTR2A | |
| SCHEMBL1094838 | 0.69 | HTR2C (0.48) | MTNR1BMTNR1AKMT2ALMNAHTR2A | |
| SCHEMBL4936392 | 0.69 | HTR2C (0.48) | MTNR1BMTNR1AKMT2ALMNAHTR2A | |
| SCHEMBL10350524 | 0.69 | HTR2A (0.54) | MTNR1BMTNR1AKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411881-A4 | 5HT sb 2C /sb RECEPTOR MODULATORS | ARENA PHARM INC (US) | 2004-07-07 | — | — | EP | disclosed |
| EP-1411881-A2 | 5HT sb 2C /sb RECEPTOR MODULATORS | Arena Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003086306-A2 | 5HT2C RECEPTOR MODULATORS | ARENA PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |