Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2762440 | 0.84 | HTT (0.52) | HTTGFERSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL22813664 | 0.84 | KMT2A (0.52) | ALDH1A1KMT2A | |
| SCHEMBL17572090 | 0.82 | HTT (0.61) | HTTGFERSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL19423896 | 0.81 | HTT (0.60) | HTTGFERSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL19356243 | 0.81 | HTT (0.60) | HTTGFERSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL12988833 | 0.80 | ECE2 (0.51) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL17572088 | 0.79 | HTT (0.61) | HTTGFERSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL23095882 | 0.78 | HTT (0.57) | HTTGFERSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL19419479 | 0.78 | HTT (0.57) | HTTGFERSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL11304999 | 0.78 | HTT (0.60) | HTTGFERSMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2693882-B1 | SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK SHARP & DOHME (US) | 2017-06-28 | — | — | EP | disclosed |