Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MASP2 | O00187 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 4/20 | 0.36 |
| ▸ | PPIB | P23284 | 1/20 | 0.35 |
| ▸ | CPB1 | P15086 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1901204 | 1.00 | MASP2 (0.42) | MASP2MAPK1SMN1; SMN2BACE1CYP3A4 | |
| SCHEMBL1431929 | 0.87 | MASP2 (0.46) | MASP2SMN1; SMN2CYP3A4ALDH1A1CPB2 | |
| SCHEMBL3139463 | 0.87 | MASP2 (0.46) | MASP2SMN1; SMN2CYP3A4ALDH1A1CPB2 | |
| SCHEMBL3148057 | 0.86 | MASP2 (0.43) | MASP2SMN1; SMN2CYP3A4ALDH1A1CPB2 | |
| SCHEMBL3148062 | 0.86 | MASP2 (0.43) | MASP2SMN1; SMN2CYP3A4ALDH1A1CPB2 | |
| SCHEMBL1903965 | 0.85 | MMP3 (0.47) | MASP2CPB2 | |
| SCHEMBL3149202 | 0.84 | MASP2 (0.42) | MASP2CYP3A4ALDH1A1CPB2PPIB | |
| SCHEMBL3149186 | 0.84 | MASP2 (0.42) | MASP2CYP3A4ALDH1A1CPB2PPIB | |
| SCHEMBL1432085 | 0.84 | MASP2 (0.44) | MASP2CYP3A4CPB2PPIB | |
| SCHEMBL1433675 | 0.84 | MASP2 (0.43) | MASP2CYP3A4ALDH1A1CPB2PPIB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |