SCHEMBL1906406

SCHEMBL1906406

C=CCNc1ccc(O)c2c1C(=O)c1ccccc1C2=O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 10/20 0.56
MEN1 O00255 9/20 0.56
MAPT P10636 7/20 0.56
MAOA P21397 4/20 0.56
TDP1 Q9NUW8 6/20 0.50
MAPK1 P28482 6/20 0.50
LMNA P02545 5/20 0.50
L3MBTL1 Q9Y468 5/20 0.50
NPC1 O15118 3/20 0.50
RAB9A P51151 3/20 0.50
NPSR1 Q6W5P4 3/20 0.50
MTOR P42345 2/20 0.49
SIRT2 Q8IXJ6 1/20 0.49
POLB P06746 5/20 0.49
ALDH1A1 P00352 5/20 0.49
BLM P54132 4/20 0.49
NSD2 O96028 3/20 0.49
HTT P42858 2/20 0.49
RXFP1 Q9HBX9 1/20 0.49
MITF O75030 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5420918 0.91 KMT2A (0.57) KMT2AMEN1MAPTMAOATDP1
SCHEMBL11046399 0.89 CYP19A1 (0.57) KMT2AMEN1MAPTMAOATDP1
SCHEMBL1478995 0.89 CYP19A1 (0.57) KMT2AMEN1MAPTMAOATDP1
SCHEMBL12658834 0.84 MAPT (0.53) KMT2AMEN1MAPTMAOATDP1
SCHEMBL10622223 0.83 MEN1 (0.53) KMT2AMEN1MAPTMAOATDP1
SCHEMBL5718287 0.82 KMT2A (0.49) KMT2AMEN1MAPTMAOATDP1
SCHEMBL8428746 0.80 MEN1 (0.61) KMT2AMEN1MAPTMAOATDP1
SCHEMBL1906212 0.80 MAPT (0.56) KMT2AMEN1MAPTMAOATDP1
SCHEMBL8428873 0.79 TOP2B (0.70) KMT2AMEN1MAPTMAOATDP1
SCHEMBL2859431 0.78 MAPT (0.51) KMT2AMEN1MAPTMAOATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1994029387-A1 ALLYLAMINOANTHRAQUINONES AND THEIR USE AS DYESTUFFS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1994-12-22 WO claimed
JP-6256777-A None JP disclosed
EP-2826564-B1 MICROWELL ARRAY ARTICLES AND METHODS OF USE 3M INNOVATIVE PROPERTIES CO (US) 2018-12-26 EP disclosed
US-9880102-B2 Microwell array articles and methods of use 3M INNOVATIVE PROPERTIES COMPANY (US) 2018-01-30 US disclosed
US-20170363545-A1 MICROWELL ARRAY ARTICLES AND METHODS OF USE 3M INNOVATIVE PROPERTIES CO (US) 2017-12-21 US disclosed
US-9759663-B2 Microwell array articles and methods of use 3M INNOVATIVE PROPERTIES COMPANY (US) 2017-09-12 US disclosed
US-20160025637-A1 MICROWELL ARRAY ARTICLES AND METHODS OF USE 3M INNOVATIVE PROPERTIES COMPANY 2016-01-28 US disclosed
EP-2826564-A1 Microwell array articles and methods of use 3M Innovative Properties Company of 3M Center (US) 2015-01-21 EP disclosed
US-20130004967-A1 MICROWELL ARRAY ARTICLES AND METHODS OF USE 3M INNOVATIVE PROPERTIES COMPANY 2013-01-03 US disclosed
EP-2504103-A2 MICROWELL ARRAY ARTICLES AND METHODS OF USE 3M Innovative Properties Company (US) 2012-10-03 EP disclosed
WO-2011063332-A2 MICROWELL ARRAY ARTICLES AND METHODS OF USE 3M INNOVATIVE PROPERTIES COMPANY (US) 2011-05-26 WO disclosed
JP-H06256777-A MARKER FOR PETROLEUM, MARKING AND DETECTING MORTON INTERNATL INC 1994-09-13 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130004967-A1 MICROWELL ARRAY ARTICLES AND METHODS OF USE CD68, ANXA2, ANXA5 KMT2A 4489/4885MEN1 3326/4885MAPT 1788/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.