Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL149399 | 0.99 | BCHE (0.42) | BCHEADRB2ADRB1ADRB3KDM4E | |
| Hydrochloric Acid SCHEMBL145663 | 0.86 | BCHE (0.46) | BCHEADRB2ADRB1ADRB3KDM4E | |
| SCHEMBL14172482 | 0.83 | BCHE (0.64) | BCHEADRB2ADRB1ADRB3KDM4E | |
| Hydrochloric Acid SCHEMBL4502753 | 0.82 | BCHE (0.63) | BCHEADRB2ADRB1ADRB3KDM4E | |
| SCHEMBL131671 | 0.82 | BCHE (0.45) | BCHEADRB2ADRB1ADRB3KDM4E | |
| SCHEMBL16111662 | 0.82 | NAAA (0.44) | BCHEADRB2ADRB1ADRB3NAAA | |
| Hydrochloric Acid SCHEMBL16107011 | 0.81 | NAAA (0.43) | BCHEADRB2ADRB1ADRB3NAAA | |
| SCHEMBL6393104 | 0.80 | KDM4C (0.51) | BCHEKDM4EMAPTPKMMEN1 | |
| Hydrochloric Acid SCHEMBL148164 | 0.79 | BCHE (0.48) | BCHEKDM4ENAAAPPARD | |
| SCHEMBL6380551 | 0.79 | BCHE (0.54) | BCHEKDM4EMAPTPKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120059032-A1 | 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES EFFECTIVE AS ANTIGLIOMA AGENTS, METHODS OF MAKING, AND THEIR USE | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120059032-A1 | 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES EFFECTIVE AS ANTIGLIOMA AGENTS, METHODS OF MAKING, AND THEIR USE | BAD, BAK1, CASP3 | BCHE 1788/4885ADRB2 3416/4885ADRB1 3764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.