Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 7/20 | 0.50 |
| ▸ | KLK1 | P06870 | 4/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MASP2 | O00187 | 3/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | FCER2 | P06734 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1906005 | 0.84 | KLKB1 (0.43) | KLKB1KLK1MASP2MMP1FCER2 | |
| SCHEMBL1902781 | 0.84 | KLKB1 (0.43) | KLKB1KLK1CTSSCTSKMMP8 | |
| SCHEMBL1906002 | 0.84 | KLKB1 (0.43) | KLKB1KLK1MASP2MMP1FCER2 | |
| SCHEMBL1904884 | 0.84 | KLKB1 (0.43) | KLKB1KLK1CTSSCTSKMMP8 | |
| SCHEMBL1902345 | 0.83 | KLKB1 (0.47) | KLKB1KLK1MMP8MASP2MMP1 | |
| SCHEMBL1903189 | 0.83 | ALDH1A1 (0.49) | KLKB1KLK1MMP8MASP2MMP1 | |
| SCHEMBL1903197 | 0.83 | ALDH1A1 (0.49) | KLKB1KLK1MMP8MASP2MMP1 | |
| SCHEMBL1906052 | 0.83 | KLKB1 (0.47) | KLKB1KLK1MMP8MASP2MMP1 | |
| SCHEMBL1904566 | 0.83 | KLKB1 (0.43) | KLKB1KLK1MASP2MMP1FCER2 | |
| SCHEMBL1432922 | 0.82 | KLKB1 (0.49) | KLKB1KLK1CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |