Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 4/20 | 0.49 |
| ▸ | KLK1 | P06870 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MASP2 | O00187 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | GZMB | P10144 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1431728 | 0.90 | KLKB1 (0.46) | KLKB1KLK1MMP2MMP9MMP8 | |
| SCHEMBL1431938 | 0.82 | ACE (0.45) | KLKB1MASP2 | |
| SCHEMBL1431596 | 0.82 | MASP2 (0.39) | KLKB1KLK1TP53MASP2 | |
| SCHEMBL1906443 | 0.82 | KLKB1 (0.50) | KLKB1KLK1MMP2MMP9MMP8 | |
| SCHEMBL1431649 | 0.82 | HTT (0.43) | KLKB1KLK1MASP2 | |
| SCHEMBL1431636 | 0.82 | MME (0.43) | KLKB1KLK1CTSSCTSKMASP2 | |
| SCHEMBL1431722 | 0.81 | MASP2 (0.40) | KLKB1CTSLTP53MASP2OPRD1 | |
| SCHEMBL1432883 | 0.80 | FURIN (0.40) | KLKB1MASP2 | |
| SCHEMBL1432300 | 0.80 | MASP2 (0.40) | KLKB1MASP2 | |
| SCHEMBL1432034 | 0.80 | CTSB (0.43) | KLKB1KLK1CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300428-A1 | AMINOPYRIDINE DERIVATIVES | Vantia Limited (GB) | 2011-03-30 | — | — | EP | disclosed |