Alpha-Naphthoflavone

Alpha-Naphthoflavone

SCHEMBL1906540

O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12.O=c1ccc2ccccc2o1

nearest known ligand 0.80

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 14/20 0.80
CYP1B1 Q16678 14/20 0.80
CYP1A2 P05177 13/20 0.80
PRKDC P78527 4/20 0.80
CYP19A1 P11511 2/20 0.80
KDM4E B2RXH2 2/20 0.80
ABCB1 P08183 2/20 0.80
ABCC1 P33527 2/20 0.80
ABCG2 Q9UNQ0 2/20 0.80
PDE5A O76074 1/20 0.80
ALDH1A1 P00352 1/20 0.80
TP53 P04637 1/20 0.80
CYP3A4 P08684 1/20 0.80
CYP2D6 P10635 1/20 0.80
MAPT P10636 1/20 0.80
CYP2C9 P11712 1/20 0.80
HPGD P15428 1/20 0.80
TSHR P16473 1/20 0.80
CYP2B6 P20813 1/20 0.80
TACR2 P21452 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alpha-Naphthoflavone SCHEMBL29351090 0.89 CYP1A1 (1.00) CYP1A1CYP1B1CYP1A2PRKDCCYP19A1
Alpha-Naphthoflavone SCHEMBL121594 0.89 CYP1A1 (1.00) CYP1A1CYP1B1CYP1A2PRKDCCYP19A1
Flavone SCHEMBL8613810 0.87 TNKS (0.74) CYP1A1CYP1B1CYP1A2PRKDCCYP19A1
Alpha-Naphthoflavone SCHEMBL3665037 0.83 CYP1A1 (0.82) CYP1A1CYP1B1CYP1A2PRKDCCYP19A1
Alpha-Naphthoflavone SCHEMBL17292887 0.82 CYP1A1 (0.84) CYP1A1CYP1B1CYP1A2PRKDCCYP19A1
SCHEMBL31061133 0.79 PRKDC (1.00) CYP1A1CYP1B1CYP1A2PRKDCCYP19A1
SCHEMBL30917246 0.79 CYP1A1 (1.00) CYP1A1CYP1B1CYP1A2PRKDCCYP19A1
SCHEMBL20594586 0.79 CYP1A1 (0.78) CYP1A1CYP1B1CYP1A2PRKDCCYP19A1
SCHEMBL4069839 0.79 CYP1A1 (1.00) CYP1A1CYP1B1CYP1A2PRKDCCYP19A1
SCHEMBL29407618 0.79 CYP1A1 (0.78) CYP1A1CYP1B1CYP1A2PRKDCCYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011050857-A2 COMPOSITIONS COMPRISING FLAVONOID-CONTAINING EXTRACTS FROM PLANTS OF THE GENUS CITRUS AND/OR ISOLATED CITRUS FLAVONOIDS AND SPECIFIC CATIONIC SURFACE ACTIVE AGENTS, AND SAID COMPOSITION FOR USE AS AN AGENT FOR TREATING INFESTATIONS WITH HEAD LICE ALPHA-BIOCARE GMBH (DE) 2011-05-05 WO disclosed