Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | FURIN | P09958 | 1/20 | 0.40 |
| ▸ | MASP2 | O00187 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1904121 | 1.00 | NAMPT (0.44) | NAMPTCTSSCTSKFURINMASP2 | |
| SCHEMBL1901309 | 0.91 | NAMPT (0.46) | NAMPTCTSSCTSKFURINMASP2 | |
| SCHEMBL1903648 | 0.90 | PDPK1 (0.42) | NAMPTFURINMASP2KLKB1GRIA1 | |
| SCHEMBL1902369 | 0.90 | PDPK1 (0.42) | NAMPTFURINMASP2KLKB1GRIA1 | |
| SCHEMBL1902787 | 0.83 | CTSS (0.63) | NAMPTCTSSCTSK | |
| SCHEMBL1904378 | 0.83 | NAMPT (0.46) | NAMPTCTSSCTSKFURINMASP2 | |
| SCHEMBL1432859 | 0.82 | NAMPT (0.43) | NAMPTCTSSCTSKFURINMASP2 | |
| SCHEMBL3144641 | 0.82 | NAMPT (0.43) | NAMPTCTSSCTSKFURINMASP2 | |
| SCHEMBL1904122 | 0.82 | NAMPT (0.43) | NAMPTFURINMASP2MEN1KMT2A | |
| SCHEMBL1906806 | 0.82 | NAMPT (0.43) | NAMPTFURINMASP2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |