Sugi Predict

Sugi Predict / Compounds / SCHEMBL19068151

SCHEMBL19068151

SCHEMBL19068151

Nc1cnc(C2CCCCCCCCC2)c(Cl)n1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDO2 P48775 2/20 0.36
▸ HRH2 P25021 1/20 0.35
▸ HRH3 Q9Y5N1 1/20 0.35
▸ BACE1 P56817 1/20 0.35
▸ FEN1 P39748 3/20 0.35
▸ OPRL1 P41146 2/20 0.35
▸ KDM4E B2RXH2 2/20 0.33
▸ MAPT P10636 1/20 0.33
▸ GFER P55789 1/20 0.33
▸ L3MBTL1 Q9Y468 2/20 0.32
▸ CDK2 P24941 1/20 0.31
▸ LCK P06239 1/20 0.31
▸ TDP1 Q9NUW8 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ ALOX5AP P20292 2/20 0.31
▸ HRH4 Q9H3N8 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ HSD17B10 Q99714 1/20 0.31
▸ APOBEC3G Q9HC16 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19069492 0.83 TDO2 (0.39) TDO2HRH2HRH3BACE1FEN1
SCHEMBL11381315 0.80 HRH2 (0.39) TDO2HRH2HRH3BACE1FEN1
SCHEMBL21013746 0.79 L3MBTL1 (0.33) OPRL1KDM4EL3MBTL1LCKTDP1
SCHEMBL30274644 0.79 CDK2 (0.31) CDK2
SCHEMBL19333210 0.79 L3MBTL1 (0.33) OPRL1KDM4EL3MBTL1LCKTDP1
SCHEMBL17432910 0.75 HRH2 (0.38) TDO2HRH2HRH3BACE1FEN1
SCHEMBL11679373 0.71 OPRL1 (0.37) TDO2OPRL1KDM4EL3MBTL1TDP1
SCHEMBL16195420 0.71 PDE10A (0.34) OPRL1ALDH1A1
SCHEMBL3843486 0.69 PDE10A (0.33) MAPTKMT2AALDH1A1HPGD
SCHEMBL3841292 0.69 PDE10A (0.42) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10640503-B2 Imidazopyridines and imidazopyrazines as LSD1 inhibitors INCYTE CORPORATION (US) 2020-05-05 — — US disclosed
US-10556908-B2 Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors INCYTE CORPORATION (US) 2020-02-11 — — US disclosed
US-20190106426-A1 IMIDAZOPYRAZINES AS LSD1 INHIBITORS INCYTE CORPORATION 2019-04-11 — — US disclosed
US-20190040058-A1 IMIDAZOPYRIDINES AND IMIDAZOPYRAZINES AS LSD1 INHIBITORS INCYTE CORPORATION 2019-02-07 — — US disclosed
US-9695168-B2 Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors INCYTE CORPORATION (US) 2017-07-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10556908-B2 Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors KDM1A, KDM1B, KDM2A TDO2 873/4885HRH2 1732/4885HRH3 1273/4885
US-20190040058-A1 IMIDAZOPYRIDINES AND IMIDAZOPYRAZINES AS LSD1 INHIBITORS KDM5A, KDM1A, KDM1B TDO2 1227/4885HRH2 1241/4885HRH3 949/4885
US-20190106426-A1 IMIDAZOPYRAZINES AS LSD1 INHIBITORS KDM1B, KDM2A, KDM1A TDO2 510/4885HRH2 1286/4885HRH3 870/4885
US-10640503-B2 Imidazopyridines and imidazopyrazines as LSD1 inhibitors KDM5A, KDM1A, KDM1B TDO2 1227/4885HRH2 1241/4885HRH3 949/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.