Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CTH | P32929 | 1/20 | 0.36 |
| ▸ | CBS | P35520 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22932423 | 0.96 | KDM4E (0.47) | KDM4EALDH1A1GAAPOLBEPHX2 | |
| SCHEMBL22932422 | 0.85 | CYP2C19 (0.49) | KDM4EALDH1A1GAAPOLBEPHX2 | |
| SCHEMBL17808690 | 0.83 | CES2 (0.44) | KDM4EALDH1A1GAAPOLBMEN1 | |
| SCHEMBL4547565 | 0.82 | KDM4E (0.38) | KDM4EALDH1A1GAAPOLBMEN1 | |
| SCHEMBL20224728 | 0.82 | KDM4E (0.44) | KDM4EALDH1A1GAAPOLBMEN1 | |
| SCHEMBL23664671 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1GAAPOLBMEN1 | |
| SCHEMBL15697704 | 0.80 | KDM4E (0.47) | KDM4EALDH1A1GAAPOLBMEN1 | |
| SCHEMBL25729639 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1GAAPOLBMEN1 | |
| SCHEMBL24311899 | 0.79 | KDM4E (0.37) | KDM4EALDH1A1GAAPOLBMEN1 | |
| SCHEMBL4402902 | 0.79 | KDM4E (0.43) | KDM4EALDH1A1GAAPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695170-B2 | Naphthyridine derivatives as inhibitors of Hypoxia inducible factor (HIF) hydroxylase | FIBROGEN, INC. (US) | 2017-07-04 | — | — | US | disclosed |