Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tert-Butylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514804 | 0.96 | — | — | |
| SCHEMBL26368 | 0.96 | — | — | |
| SCHEMBL4559131 | 0.96 | TSHR (0.33) | TSHRTDP1 | |
| Methylamine SCHEMBL6868266 | 0.92 | TSHR (0.31) | TSHRTDP1 | |
| Iodide SCHEMBL5273257 | 0.92 | TSHR (0.31) | TSHRTDP1 | |
| Hydrochloric Acid SCHEMBL2860424 | 0.92 | TSHR (0.31) | TSHRTDP1 | |
| SCHEMBL2176867 | 0.79 | — | — | |
| SCHEMBL6404692 | 0.79 | CYP2D6 (0.32) | — | |
| Sulfuric Acid SCHEMBL297467 | 0.78 | CA5A (0.33) | TSHR | |
| Diaminooctane SCHEMBL6864725 | 0.78 | DNM1 (0.44) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091745-B1 | TREATMENT OF HYPERPROLIFERATIVE DISORDERS | CHILDREN S HOSPITAL LOS ANGELE (US) | 2008-10-01 | — | — | EP | claimed |
| EP-2669267-B1 | Compositions and methods for treating hyperproliferative disorders | TEXAS TECH UNIV (US) | 2018-01-10 | — | — | EP | disclosed |
| EP-1594544-B1 | ORAL COMPOSITIONS OF FENRETINIDE HAVING INCREASED BIOAVAILABILITY AND METHODS OF USING THE SAME | LOS ANGELES CHILDRENS HOSPITAL (US) | 2016-04-06 | — | — | EP | disclosed |
| EP-2669267-A1 | Compositions and methods for treating hyperproliferative disorders | TEXAS TECH UNIVERSITY (US) | 2013-12-04 | — | — | EP | disclosed |
| EP-2501672-A2 | COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISORDERS | TEXAS TECH UNIVERSITY (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060332-A2 | COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISORDERS | TEXAS TECH UNIVERSITY (US) | 2011-05-19 | — | — | WO | disclosed |
| US-7785621-B2 | Oral compositions of fenretinide having increased bioavailability and methods of using the same | CHILDRENS HOSPITAL LOS ANGELES (US) | 2010-08-31 | — | — | US | disclosed |
| EP-1349545-B1 | PHARMACEUTICAL COMPOSITIONS OF FENRETINIDE HAVING INCREASED BIOAVAILABILITY AND METHODS OF USING THE SAME | LOS ANGELES CHILDRENS HOSPITAL (US) | 2008-11-19 | — | — | EP | disclosed |
| EP-1091745-B1 | TREATMENT OF HYPERPROLIFERATIVE DISORDERS | CHILDREN S HOSPITAL LOS ANGELE (US) | 2008-10-01 | — | — | EP | disclosed |
| EP-1349545-A4 | PHARMACEUTICAL COMPOSITIONS OF FENRETINIDE HAVING INCREASED BIOAVAILABILITY AND METHODS OF USING THE SAME | LOS ANGELES CHILDRENS HOSPITAL (US) | 2006-05-24 | — | — | EP | disclosed |
| EP-1091745-A4 | TREATMENT OF HYPERPROLIFERATIVE DISORDERS | LOS ANGELES CHILDRENS HOSPITAL (US) | 2003-08-27 | — | — | EP | disclosed |
| EP-1239851-A1 | TREATMENT OF HYPERPROLIFERATIVE DISORDERS | CHILDRENS HOSPITAL OF LOS ANGELES (US) | 2002-09-18 | — | — | EP | disclosed |
| WO-2002058689-A1 | PHARMACEUTICAL COMPOSITIONS OF FENRETINIDE HAVING INCREASED BIOAVAILABILITY AND METHODS OF USING THE SAME | CHILDRENS HOSPITAL LOS ANGELES (US) | 2002-08-01 | — | — | WO | disclosed |
| US-6368831-B1 | ANTIPROLIFERATION AGENTS | CHILDRENS HOSPITAL LOS ANGELES | 2002-04-09 | — | — | US | disclosed |
| US-6352844-B1 | CERAMIDE GENERATING RETINOIDS AND INHIBITORS OF TUMORS | CHILDRENS HOSPITAL LOS ANGELES | 2002-03-05 | — | — | US | disclosed |
| WO-2001047513-A1 | TREATMENT OF HYPERPROLIFERATIVE DISORDERS | CHILDRENS HOSPITAL LOS ANGELES RESEARCH INSTITUTE (US) | 2001-07-05 | — | — | WO | disclosed |
| EP-1091745-A1 | TREATMENT OF HYPERPROLIFERATIVE DISORDERS | CHILDREN'S HOSPITAL OF LOS ANGELES (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-2001007914-A1 | FENRETINIDE INCREASES ANTIBODY CELLULAR TOXICITY | CHILDRENS HOSPITAL LOS ANGELES RESEARCH INSTITUTE (US) | 2001-02-01 | — | — | WO | disclosed |
| WO-2000000207-A9 | TREATMENT OF HYPERPROLIFERATIVE DISORDERS | LOS ANGELES CHILDRENS HOSPITAL (US) | 2000-05-18 | — | — | WO | disclosed |
| WO-2000000207-A1 | TREATMENT OF HYPERPROLIFERATIVE DISORDERS | CHILDREN'S HOSPITAL OF LOS ANGELES (US) | 2000-01-06 | — | — | WO | disclosed |