Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 4/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 6/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.42 |
| ▸ | PIM1 | P11309 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4761409 | 0.85 | MAPK11 (0.52) | MAPK11MAPK14PIM3PIM2PIM1 | |
| SCHEMBL4761470 | 0.84 | MAPK11 (0.52) | MAPK11MAPK14PIM3PIM2PIM1 | |
| SCHEMBL4761674 | 0.83 | MAPK11 (0.51) | MAPK11MAPK14PIM3PIM2PIM1 | |
| SCHEMBL4830402 | 0.83 | MAPK11 (0.50) | MAPK11MAPK14PIM3PIM2PIM1 | |
| SCHEMBL3373577 | 0.80 | MAPK11 (0.59) | MAPK11MAPK14KCNH2TLR7 | |
| SCHEMBL4762891 | 0.80 | MAPK11 (0.52) | MAPK11MAPK14PIM3PIM2PIM1 | |
| SCHEMBL4761678 | 0.80 | MAPK14 (0.52) | MAPK11MAPK14PIM3PIM2PIM1 | |
| SCHEMBL6004032 | 0.78 | MAPK11 (0.48) | MAPK11MAPK14PIM1KCNH2TLR7 | |
| SCHEMBL4865422 | 0.77 | MAPK14 (0.52) | MAPK11MAPK14KCNH2KDM4ESMN1; SMN2 | |
| Isopropylamine SCHEMBL4890140 | 0.76 | MAPK11 (0.53) | MAPK11MAPK14KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320904-A2 | AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | Kalypsys, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |