Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | GLI1 | P08151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15995652 | 0.76 | NOS2 (0.36) | NOS2KDM4ECYP2D6NPC1CYP1A2 | |
| SCHEMBL717000 | 0.76 | NOS2 (0.36) | NOS2KDM4ECYP2D6NPC1CYP1A2 | |
| SCHEMBL717921 | 0.76 | NOS2 (0.36) | NOS2KDM4ECYP2D6NPC1CYP1A2 | |
| SCHEMBL1907489 | 0.75 | PRCP (0.34) | NOS2KDM4ECYP2D6NPC1CYP1A2 | |
| SCHEMBL1907491 | 0.75 | PRCP (0.31) | NOS2KDM4ECYP2D6NPC1CYP1A2 | |
| SCHEMBL16165634 | 0.72 | KDM4E (0.40) | NOS2KDM4ECYP2D6NPC1CYP1A2 | |
| SCHEMBL14622051 | 0.71 | KDM4E (0.42) | NOS2KDM4ECYP2D6NPC1CYP1A2 | |
| SCHEMBL5447760 | 0.71 | KDM4E (0.42) | NOS2KDM4ECYP2D6NPC1CYP1A2 | |
| SCHEMBL8283621 | 0.70 | CCR2 (0.33) | NOS2KDM4ECYP2D6NPC1CYP1A2 | |
| SCHEMBL8471413 | 0.70 | CCR2 (0.33) | NOS2KDM4ECYP2D6NPC1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493846-A1 | 2-ARYL-PROPIONAMIDE DERIVATIVES USEFUL AS BRADYKININ RECEPTOR ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dompe S.p.A. (IT) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011051375-A1 | 2-ARYL-PROPIONAMIDE DERIVATIVES USEFUL AS BRADYKININ RECEPTOR ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dompé S.p.A. (IT) | 2011-05-05 | — | — | WO | disclosed |