Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846371 | 0.90 | L3MBTL1 (0.44) | L3MBTL1KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL879437 | 0.90 | L3MBTL1 (0.46) | L3MBTL1KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL10305700 | 0.88 | L3MBTL1 (0.42) | L3MBTL1KDM4EMEN1ALDH1A1POLB | |
| Sipagladenant SCHEMBL879438 | 0.87 | L3MBTL1 (0.47) | L3MBTL1KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL846999 | 0.86 | L3MBTL1 (0.43) | L3MBTL1KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL10331934 | 0.86 | L3MBTL1 (0.46) | L3MBTL1KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL846961 | 0.85 | L3MBTL1 (0.42) | L3MBTL1KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL846810 | 0.85 | L3MBTL1 (0.43) | L3MBTL1KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL1255678 | 0.85 | ALDH1A1 (0.52) | L3MBTL1KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL1257097 | 0.85 | L3MBTL1 (0.46) | L3MBTL1KDM4EMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2308509-B1 | INHIBITOR OF ANALGESIC TOLERANCE | KYOWA HAKKO KIRIN CO LTD (JP) | 2017-07-05 | — | — | EP | disclosed |