Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19079591 | 0.82 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAGAAKDM1AMAOB | |
| SCHEMBL19064370 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAGAAKDM1AMAOB | |
| SCHEMBL19064371 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAGAAKDM1AMAOB | |
| SCHEMBL19079593 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAGAAKDM1AMAOB | |
| SCHEMBL17594833 | 0.78 | LMNA (0.37) | SMN1; SMN2LMNAGAAKDM1AMAOB | |
| SCHEMBL17594834 | 0.78 | LMNA (0.37) | SMN1; SMN2LMNAGAAKDM1AMAOB | |
| SCHEMBL19742959 | 0.71 | NPC1 (0.64) | SMYD3NPC1RAB9A | |
| SCHEMBL7456808 | 0.70 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAGAAKDM1AMAOB | |
| SCHEMBL10343938 | 0.68 | BTK (0.61) | GAAKDM1AMAOBBTKDRD2 | |
| SCHEMBL3702152 | 0.68 | BTK (0.61) | GAAKDM1AMAOBBTKDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170190676-A1 | Isoxazole Carboxamide Compounds | Epizyme, Inc. (US) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190676-A1 | Isoxazole Carboxamide Compounds | SMYD3, SMYD2, SNRPD3 | SMN1; SMN2 248/4885LMNA 4283/4885GAA 2791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.