Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22544270 | 0.85 | RAD52 (0.49) | DRD2DRD3RAD52RECQLCYP3A4 | |
| SCHEMBL19080440 | 0.79 | CDK1 (0.32) | MAPTPNMTLMNAL3MBTL3 | |
| SCHEMBL16644163 | 0.77 | HTR1D (0.36) | DRD2DRD3MAPTKDM4EGAA | |
| SCHEMBL23529940 | 0.76 | CCR1 (0.37) | PNMTL3MBTL3 | |
| SCHEMBL19080439 | 0.75 | SLC6A9 (0.37) | — | |
| SCHEMBL19504664 | 0.75 | HTT (0.36) | KCNH2GABRG2GABRB3GABRA5 | |
| SCHEMBL15242530 | 0.74 | DRD3 (0.40) | DRD2DRD3MAPTKDM4ELMNA | |
| SCHEMBL11075570 | 0.73 | RAD52 (0.36) | RAD52RECQLCYP3A4TSHRHSD17B10 | |
| SCHEMBL16639804 | 0.73 | DRD2 (0.34) | DRD2DRD3KCNH2CHRNB2CHRNA4 | |
| SCHEMBL20651755 | 0.71 | DRD2 (0.33) | DRD2DRD3MAPTSMN1; SMN2CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017117447-A1 | MULTICYCLIC COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. (US) | 2017-07-06 | — | — | WO | disclosed |