Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902949 | 0.83 | AKT1 (0.36) | TNK2AKT1 | |
| SCHEMBL1900820 | 0.83 | MERTK (0.34) | TNK2AKT1PTGS2 | |
| SCHEMBL1902848 | 0.81 | TACR3 (0.37) | TNK2AKT1PTGS2 | |
| SCHEMBL1907910 | 0.80 | AKT1 (0.42) | TNK2AKT1 | |
| SCHEMBL1905294 | 0.80 | AKT1 (0.32) | TNK2AKT1 | |
| SCHEMBL1907828 | 0.77 | AKT1 (0.37) | AKT1PTGS2 | |
| SCHEMBL1898953 | 0.77 | AKT1 (0.37) | AKT1PTGS2 | |
| SCHEMBL1907661 | 0.74 | CHEK1 (0.35) | TNK2AKT1 | |
| SCHEMBL1907310 | 0.74 | KDM4E (0.31) | AKT1 | |
| SCHEMBL1534906 | 0.74 | ATR (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011055115-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2011-05-12 | — | — | WO | disclosed |