Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1907661 | 0.92 | CHEK1 (0.35) | AKT1TNK2LCKCHEK1MERTK | |
| SCHEMBL1902949 | 0.81 | AKT1 (0.36) | AKT1TNK2LCKCHEK1MERTK | |
| SCHEMBL1908162 | 0.80 | OPRM1 (0.32) | AKT1TNK2 | |
| SCHEMBL14118957 | 0.79 | TACR3 (0.41) | AKT1CHEK1 | |
| SCHEMBL1907828 | 0.79 | AKT1 (0.37) | AKT1 | |
| SCHEMBL1905644 | 0.78 | AKT1 (0.51) | AKT1 | |
| SCHEMBL1908428 | 0.77 | MERTK (0.35) | AKT1TNK2LCKCHEK1MERTK | |
| SCHEMBL1898953 | 0.77 | AKT1 (0.37) | AKT1 | |
| SCHEMBL14119116 | 0.75 | AKT1 (0.42) | AKT1 | |
| SCHEMBL1905018 | 0.75 | EGFR (0.34) | AKT1TNK2LCKMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011055115-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2011-05-12 | — | — | WO | disclosed |