Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | HTR2C | P28335 | 4/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 7/20 | 0.46 |
| ▸ | DRD3 | P35462 | 6/20 | 0.46 |
| ▸ | DRD1 | P21728 | 5/20 | 0.46 |
| ▸ | DRD5 | P21918 | 5/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1906400 | 0.84 | DRD2 (0.53) | HTR2AHTR2CDRD2DRD3DRD1 | |
| SCHEMBL2625795 | 0.79 | HTR2A (0.55) | HTR2AHTR2CHTR2BDRD2DRD3 | |
| SCHEMBL2201535 | 0.78 | HTR2A (0.56) | HTR2AHTR2CHTR2BDRD2DRD1 | |
| SCHEMBL30888613 | 0.78 | HTR2A (0.42) | HTR2AHTR2CHTR2BNPSR1SIGMAR1 | |
| SCHEMBL29991968 | 0.78 | HTR2A (0.42) | HTR2AHTR2CHTR2BSIGMAR1SLC6A4 | |
| SCHEMBL2202642 | 0.75 | HTR2A (0.43) | HTR2AHTR2CHTR2BDRD2DRD1 | |
| SCHEMBL20365097 | 0.74 | HTR2A (0.58) | HTR2AHTR2CHTR2BDRD2DRD3 | |
| SCHEMBL12705960 | 0.74 | DRD2 (0.54) | DRD2DRD3DRD1DRD5MAOA | |
| SCHEMBL13672966 | 0.72 | HTR2C (0.59) | HTR2AHTR2CHTR2BDRD2DRD1 | |
| SCHEMBL21008386 | 0.72 | HTR2A (0.56) | HTR2AHTR2CHTR2BDRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322162-A1 | 5HT2C receptor modulator compositions and methods of use | Arena Pharmaceuticals, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |