Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30888613 | 0.95 | HTR2A (0.42) | HTR2AHTR2CHTR2BNPC1RAB9A | |
| SCHEMBL5750905 | 0.81 | GRIN2D (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1GRIN2D | |
| SCHEMBL5751880 | 0.81 | SIGMAR1 (0.43) | HTR2AHTR2CHTR2BNPC1RAB9A | |
| SCHEMBL13672966 | 0.79 | HTR2C (0.59) | HTR2AHTR2CHTR2B | |
| SCHEMBL1908242 | 0.78 | HTR2A (0.47) | HTR2AHTR2CHTR2BSLC6A4SIGMAR1 | |
| SCHEMBL30888604 | 0.78 | MAOA (0.49) | HTR2AHTR2CHTR2BCYP11B1CYP11B2 | |
| Ethane SCHEMBL27451716 | 0.76 | GRIN2D (0.37) | NPC1RAB9ASMN1; SMN2ALDH1A1PTGS2 | |
| SCHEMBL30315317 | 0.75 | SIGMAR1 (0.43) | HTR2AHTR2CHTR2BSMN1; SMN2KDM1A | |
| SCHEMBL5722761 | 0.75 | CDC25B (0.42) | NPC1RAB9ASMN1; SMN2ALDH1A1GRIN2D | |
| SCHEMBL30236891 | 0.74 | CYP2A6 (0.41) | HTR2AHTR2CHTR2BKDM1AKDM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220332708-A1 | SULFONAMIDE COMPOUNDS AS CARDIAC SARCOMERE ACTIVATORS | CYTOKINETICS INC (US) | 2022-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220332708-A1 | SULFONAMIDE COMPOUNDS AS CARDIAC SARCOMERE ACTIVATORS | TNNT2, TNNI3, MYLK2 | HTR2A 2280/4885HTR2C 3812/4885HTR2B 3319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.