Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 6/20 | 1.00 |
| ▸ | KDM1A | O60341 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.55 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.55 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.55 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.55 |
| ▸ | CCR9 | P51686 | 3/20 | 0.55 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12570805 | 0.88 | METAP2 (0.86) | METAP2CYP2C9CYP1A2MCL1LMNA | |
| SCHEMBL6432619 | 0.86 | METAP2 (0.76) | METAP2KDM1ACYP2C9CYP1A2SLC10A2 | |
| SCHEMBL5925257 | 0.86 | METAP2 (1.00) | METAP2KDM1ASLC10A2SLC10A1SLC10A6 | |
| SCHEMBL29148 | 0.86 | METAP2 (0.75) | METAP2CYP2C9CYP1A2SLC10A6CCR9 | |
| SCHEMBL16496289 | 0.86 | METAP2 (0.75) | METAP2KDM1ACYP2C9CYP1A2MCL1 | |
| SCHEMBL4649665 | 0.85 | METAP2 (0.74) | METAP2KDM1AMCL1SLC10A2SLC10A1 | |
| SCHEMBL6348358 | 0.84 | METAP2 (0.71) | METAP2KDM1ASLC10A2SLC10A1SLC10A6 | |
| SCHEMBL9164473 | 0.83 | METAP2 (0.85) | METAP2CYP2C9CYP1A2CCR9LMNA | |
| SCHEMBL12200769 | 0.83 | METAP2 (0.71) | METAP2KDM1ACYP2C9CYP1A2MCL1 | |
| SCHEMBL28841487 | 0.82 | METAP2 (0.70) | METAP2KDM1ACYP2C9CYP1A2CCR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170190675-A1 | CHEMICAL MODULATORS OF IMMUNE CHECKPOINTS AND THERAPEUTIC USE | DUKE UNIVERSITY | 2017-07-06 | — | — | US | disclosed |
| US-20170190675-A1 | CHEMICAL MODULATORS OF IMMUNE CHECKPOINTS AND THERAPEUTIC USE | DUKE UNIVERSITY | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190675-A1 | CHEMICAL MODULATORS OF IMMUNE CHECKPOINTS AND THERAPEUTIC USE | CD274, PDCD1, PDCD1LG2 | METAP2 2068/4885KDM1A 433/4885CYP2C9 4747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.