Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.76 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CCR9 | P51686 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.53 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.53 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | TCF4 | P15884 | 1/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3981560 | 0.88 | METAP2 (0.62) | METAP2CYP2C9CCR9LMNASLC10A2 | |
| SCHEMBL19083016 | 0.86 | METAP2 (1.00) | METAP2CYP2C9CCR9LMNASLC10A2 | |
| SCHEMBL4649661 | 0.86 | METAP2 (0.57) | METAP2CCR9SLC10A2SLC10A1SLC10A6 | |
| SCHEMBL3511869 | 0.85 | FFAR4 (0.62) | METAP2FFAR4CYP2C9LMNACYP1A2 | |
| SCHEMBL23200363 | 0.84 | FFAR4 (0.65) | METAP2FFAR4CYP2C9LMNACYP1A2 | |
| SCHEMBL1291344 | 0.84 | LMNA (0.68) | METAP2FFAR4CYP2C9CCR9LMNA | |
| SCHEMBL3512980 | 0.84 | CYP2C9 (0.72) | METAP2FFAR4CYP2C9LMNACYP1A2 | |
| SCHEMBL16628393 | 0.84 | FFAR4 (0.61) | METAP2FFAR4CYP2C9LMNACYP1A2 | |
| SCHEMBL31138223 | 0.84 | FFAR4 (0.61) | METAP2FFAR4CYP2C9LMNACYP1A2 | |
| SCHEMBL31138312 | 0.84 | FFAR4 (0.65) | METAP2FFAR4CYP2C9LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936602-B1 | Benzazepine derivatives, process for the preparation of the same and uses thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-30 | — | — | US | disclosed |
| EP-1186604-A1 | BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-03-13 | — | — | EP | disclosed |