Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19083026 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2SIRT2GAAALDH1A1MEN1 | |
| SCHEMBL19083023 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2SIRT2GAAALDH1A1MEN1 | |
| SCHEMBL19083022 | 0.69 | SMN1; SMN2 (1.00) | SMN1; SMN2SIRT2GAAALDH1A1MEN1 | |
| SCHEMBL19083025 | 0.69 | SMN1; SMN2 (0.62) | SMN1; SMN2SIRT2GAAALDH1A1MEN1 | |
| SCHEMBL11841965 | 0.68 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2ALMNAPOLB | |
| SCHEMBL28803669 | 0.66 | ALDH1A1 (0.56) | SMN1; SMN2GAAALDH1A1MEN1KMT2A | |
| SCHEMBL5819247 | 0.66 | SMN1; SMN2 (0.68) | SMN1; SMN2SIRT2GAAALDH1A1MEN1 | |
| SCHEMBL19083027 | 0.65 | GAA (0.67) | SMN1; SMN2SIRT2GAAALDH1A1MEN1 | |
| SCHEMBL28478277 | 0.65 | ALDH1A1 (0.58) | SMN1; SMN2SIRT2GAAALDH1A1MEN1 | |
| SCHEMBL6404390 | 0.64 | CYP3A4 (0.60) | SMN1; SMN2SIRT2GAAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10323016-B2 | Imidazol- or 1,2,4-triazol-derivatives and their use | UNIVERSITE DE LILLE 2 DROIT ET SANTE (FR) | 2019-06-18 | — | — | US | disclosed |
| US-20170190687-A1 | IMIDAZOL- OR 1,2,4-TRIAZOL-DERIVATIVES AND THEIR USE | Université de Lille (FR) | 2017-07-06 | — | — | US | disclosed |
| US-20170190687-A1 | IMIDAZOL- OR 1,2,4-TRIAZOL-DERIVATIVES AND THEIR USE | Université de Lille (FR) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190687-A1 | IMIDAZOL- OR 1,2,4-TRIAZOL-DERIVATIVES AND THEIR USE | CYP3A43, CYP51A1, CYP3A7 | SMN1; SMN2 2642/4885SIRT2 1046/4885GAA 1282/4885 |
| US-10323016-B2 | Imidazol- or 1,2,4-triazol-derivatives and their use | CYP3A43, CYP51A1, CYP3A7 | SMN1; SMN2 2642/4885SIRT2 1046/4885GAA 1282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.