Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 4/20 | 0.35 |
| ▸ | MMP1 | P03956 | 3/20 | 0.35 |
| ▸ | MMP3 | P08254 | 2/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19083902 | 1.00 | SMN1; SMN2 (0.37) | SMN1; SMN2ALDH1A1KDM4EMAPTTHRB | |
| SCHEMBL10445869 | 0.96 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1KDM4EMAPTTHRB | |
| SCHEMBL10442216 | 0.96 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1KDM4EMAPTTHRB | |
| SCHEMBL6885724 | 0.94 | MMP2 (0.41) | SMN1; SMN2ALDH1A1PYGLKMT2AMMP2 | |
| SCHEMBL3285856 | 0.94 | MMP2 (0.41) | SMN1; SMN2ALDH1A1PYGLKMT2AMMP2 | |
| SCHEMBL329758 | 0.94 | MMP2 (0.41) | SMN1; SMN2ALDH1A1PYGLKMT2AMMP2 | |
| SCHEMBL31730569 | 0.91 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1KDM4EMAPTTHRB | |
| SCHEMBL13544389 | 0.91 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1KDM4EMAPTTHRB | |
| SCHEMBL19083735 | 0.91 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1KDM4EMAPTTHRB | |
| SCHEMBL9800440 | 0.82 | KDM4E (0.33) | SMN1; SMN2ALDH1A1KDM4EMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11149002-B2 | Therapeutic compounds and methods of use thereof | GENENTECH, INC. (US) | 2021-10-19 | — | — | US | disclosed |
| US-20210078947-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2021-03-18 | — | — | US | disclosed |
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |
| US-20170190662-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190662-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | RDX, C1R, MTX1 | SMN1; SMN2 2803/4885ALDH1A1 1155/4885KDM4E 2958/4885 |
| US-11149002-B2 | Therapeutic compounds and methods of use thereof | RDX, C1R, MTX1 | SMN1; SMN2 2803/4885ALDH1A1 1155/4885KDM4E 2958/4885 |
| US-20210078947-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | RDX, C1R, MTX1 | SMN1; SMN2 2803/4885ALDH1A1 1155/4885KDM4E 2958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.