Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | PYGL | P06737 | 3/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9800441 | 1.00 | KDM4E (0.33) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL13544389 | 0.90 | SMN1; SMN2 (0.39) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL31730569 | 0.90 | SMN1; SMN2 (0.39) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL19083735 | 0.90 | SMN1; SMN2 (0.39) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL19083742 | 0.82 | SMN1; SMN2 (0.37) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL10445869 | 0.82 | SMN1; SMN2 (0.41) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL10442216 | 0.82 | SMN1; SMN2 (0.41) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL19083902 | 0.82 | SMN1; SMN2 (0.37) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL3285856 | 0.81 | MMP2 (0.41) | SMN1; SMN2ALDH1A1DPP4PYGLCYP2C9 | |
| SCHEMBL329758 | 0.81 | MMP2 (0.41) | SMN1; SMN2ALDH1A1DPP4PYGLCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230037-B1 | CYTOPROTECTIVE DERIVATIVES USEFUL IN ISCHEMIC DISEASES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | ITALFARMACO S.p.A. (IT) | 1991-03-06 | — | — | EP | disclosed |
| US-4789681-A | CARDIOPROTECTIVE AGENTS | ITALFARMACO S.P.A. (IT) | 1988-12-06 | — | — | US | disclosed |
| EP-0230037-A1 | Cytoprotective derivatives useful in ischemic diseases, their preparation and compositions containing them | ITALFARMACO S.p.A. (IT) | 1987-07-29 | — | — | EP | disclosed |