Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | GNRHR | P30968 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.38 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19083720 | 0.87 | LRRK2 (0.46) | LRRK2BRD4LMNAALDH1A1THRB | |
| SCHEMBL19075706 | 0.82 | LRRK2 (0.44) | LRRK2BRD4LMNAALDH1A1THRB | |
| SCHEMBL19075715 | 0.80 | LRRK2 (0.47) | LRRK2BRD4LMNAALDH1A1THRB | |
| SCHEMBL19083717 | 0.75 | NPC1 (0.42) | LMNATHRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19083999 | 0.74 | HDAC8 (0.50) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19075723 | 0.68 | NPC1 (0.43) | BRD4LMNATHRBNPC1RAB9A | |
| SCHEMBL8889868 | 0.68 | ALDH1A1 (0.60) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23317129 | 0.67 | ALDH1A1 (0.59) | CYP3A4LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL8889352 | 0.67 | ALDH1A1 (0.62) | CYP3A4LMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL6963969 | 0.66 | BRD4 (0.48) | LRRK2BRD4LMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170190662-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190662-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | RDX, C1R, MTX1 | CYP3A4 594/4885LRRK2 3077/4885BRD4 1654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.