Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 3/20 | 0.44 |
| ▸ | BACE1 | P56817 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19075811 | 0.87 | BCHE (0.46) | ACHEALDH1A1TSHRBCHEBACE1 | |
| SCHEMBL19083789 | 0.86 | ALDH1A1 (0.48) | ACHEALDH1A1TSHRBCHEBACE1 | |
| SCHEMBL25531028 | 0.84 | ACHE (0.43) | ACHEALDH1A1TSHRBCHEBACE1 | |
| SCHEMBL15591085 | 0.80 | ALDH1A1 (0.68) | ACHEALDH1A1TSHRBCHEBACE1 | |
| SCHEMBL18908933 | 0.79 | ACHE (0.45) | ACHEALDH1A1TSHRBCHEBACE1 | |
| SCHEMBL25541744 | 0.76 | TSHR (0.48) | ACHEALDH1A1TSHRBCHEBACE1 | |
| SCHEMBL22255222 | 0.75 | ALDH1A1 (0.44) | ACHEALDH1A1TSHRBCHEBACE1 | |
| SCHEMBL18908857 | 0.74 | ALDH1A1 (0.43) | ACHEALDH1A1TSHRBCHEBACE1 | |
| SCHEMBL19075549 | 0.74 | ALDH1A1 (0.46) | ACHEALDH1A1TSHRBCHEBACE1 | |
| SCHEMBL19206095 | 0.74 | DRD4 (0.56) | ACHEBCHEBACE1CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170190662-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190662-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | RDX, C1R, MTX1 | ACHE 1652/4885ALDH1A1 1155/4885TSHR 475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.