Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 7/20 | 0.67 |
| ▸ | MAOA | P21397 | 7/20 | 0.67 |
| ▸ | KDM1B | Q8NB78 | 7/20 | 0.67 |
| ▸ | RCOR1 | Q9UKL0 | 7/20 | 0.67 |
| ▸ | MAOB | P27338 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PRKDC | P78527 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15777298 | 0.92 | KDM1A (0.68) | KDM1AMAOAKDM1BRCOR1MAOB | |
| SCHEMBL19084607 | 0.89 | KDM1A (0.66) | KDM1AMAOAKDM1BRCOR1MAOB | |
| SCHEMBL17302737 | 0.88 | KDM1A (0.61) | KDM1AMAOAKDM1BRCOR1MAOB | |
| SCHEMBL15777281 | 0.87 | KDM1A (0.67) | KDM1AMAOAKDM1BRCOR1MAOB | |
| SCHEMBL28808690 | 0.86 | ALDH1A1 (0.67) | KDM1AMAOAKDM1BRCOR1MAOB | |
| SCHEMBL17287400 | 0.81 | KDM1A (1.00) | KDM1AMAOAKDM1BRCOR1MAOB | |
| SCHEMBL17287398 | 0.81 | KDM1A (1.00) | KDM1AMAOAKDM1BRCOR1MAOB | |
| Hydrochloric Acid SCHEMBL17287370 | 0.81 | KDM1A (1.00) | KDM1AMAOAKDM1BRCOR1MAOB | |
| Hydrochloric Acid SCHEMBL17287369 | 0.81 | KDM1A (1.00) | KDM1AMAOAKDM1BRCOR1MAOB | |
| SCHEMBL22335151 | 0.79 | KDM1A (0.81) | KDM1AMAOAKDM1BRCOR1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10233165-B2 | Cyclopropylamine compounds as histone demethylase inhibitors | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2019-03-19 | — | — | US | disclosed |
| US-20170190680-A1 | CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-07-06 | — | — | US | disclosed |
| US-20170190680-A1 | CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10233165-B2 | Cyclopropylamine compounds as histone demethylase inhibitors | KDM1B, PHF2, KDM6B | KDM1A 12/4885MAOA 439/4885KDM1B 1/4885 |
| US-20170190680-A1 | CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | KDM1B, PHF2, KDM6B | KDM1A 12/4885MAOA 439/4885KDM1B 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.