Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.35 |
| ▸ | AKT2 | P31751 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1903884 | 0.91 | AKT2 (0.33) | AKT1AKT2BRD4OPRM1OPRL1 | |
| SCHEMBL1902498 | 0.90 | OPRM1 (0.36) | AKT1AKT2BRD4OPRM1OPRL1 | |
| SCHEMBL1905091 | 0.87 | — | — | |
| SCHEMBL12095384 | 0.84 | AKT1 (0.48) | AKT1AKT2BRD4NR4A2 | |
| SCHEMBL1904285 | 0.84 | OPRL1 (0.32) | TNK2OPRM1OPRL1 | |
| SCHEMBL1905277 | 0.82 | BRD4 (0.38) | AKT1AKT2BRD4NR4A2TNK2 | |
| SCHEMBL1907424 | 0.81 | MEN1 (0.31) | TNK2 | |
| SCHEMBL1903889 | 0.79 | KDM4E (0.30) | OPRM1KCNH2 | |
| SCHEMBL1907422 | 0.78 | KDM4E (0.30) | OPRM1KCNH2 | |
| SCHEMBL1904227 | 0.77 | LCK (0.30) | TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011055115-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2011-05-12 | — | — | WO | disclosed |