Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 19/20 | 0.61 |
| ▸ | S1PR3 | Q99500 | 12/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19084929 | 0.85 | S1PR1 (0.69) | S1PR1S1PR3 | |
| SCHEMBL19076274 | 0.84 | NPC1 (0.46) | S1PR1ESR1ESR2 | |
| SCHEMBL19084906 | 0.81 | S1PR1 (0.59) | S1PR1S1PR3 | |
| SCHEMBL20615396 | 0.76 | S1PR1 (1.00) | S1PR1S1PR3 | |
| SCHEMBL14243226 | 0.73 | HDAC6 (0.63) | ESR1ESR2 | |
| SCHEMBL19076254 | 0.73 | SMN1; SMN2 (0.57) | S1PR1ESR1ESR2 | |
| SCHEMBL25625041 | 0.71 | HDAC6 (0.55) | ESR1ESR2 | |
| SCHEMBL10173054 | 0.71 | HDAC6 (0.64) | ESR1ESR2 | |
| SCHEMBL2949797 | 0.70 | KDM4E (0.65) | S1PR1S1PR3 | |
| SCHEMBL2947283 | 0.70 | S1PR1 (0.68) | S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10300155-B2 | Alpha-synuclein ligands | WASHINGTON UNIVERSITY (US) | 2019-05-28 | — | — | US | disclosed |
| US-20170189566-A1 | ALPHA-SYNUCLEIN LIGANDS | WASHINGTON UNIVERSITY (US) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10300155-B2 | Alpha-synuclein ligands | SNCA, PARK7, LRRK2 | S1PR1 1435/4885S1PR3 1147/4885ESR1 4792/4885 |
| US-20170189566-A1 | ALPHA-SYNUCLEIN LIGANDS | SNCA, PARK7, LRRK2 | S1PR1 1435/4885S1PR3 1147/4885ESR1 4792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.