SCHEMBL19085063

SCHEMBL19085063

NC(=O)Nc1ccc(C2CCCC2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 3/20 0.58
HDAC6 Q9UBN7 3/20 0.58
HDAC3 O15379 2/20 0.58
HDAC11 Q96DB2 2/20 0.58
DEGS1 O15121 1/20 0.58
MITF O75030 1/20 0.54
KLF5 Q13887 1/20 0.54
ALDH1A1 P00352 7/20 0.52
HPGD P15428 2/20 0.52
PEPD P12955 1/20 0.52
HDAC1 Q13547 1/20 0.51
NPC1 O15118 3/20 0.50
USP2 O75604 2/20 0.50
SLC18A3 Q16572 1/20 0.49
GAA P10253 1/20 0.47
MAPT P10636 1/20 0.47
GFER P55789 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
RORC P51449 1/20 0.47
ALOX15 P16050 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7760744 0.98 HDAC8 (0.60) HDAC8HDAC6HDAC3HDAC11DEGS1
SCHEMBL12810977 0.92 HDAC3 (0.57) HDAC8HDAC6HDAC3HDAC11DEGS1
SCHEMBL31037442 0.84 NAMPT (0.59)
SCHEMBL11356835 0.83 HDAC8 (0.64) HDAC8HDAC6HDAC3HDAC11DEGS1
SCHEMBL15157030 0.81 SLC18A3 (0.68) HDAC8HDAC6HDAC3HDAC11DEGS1
SCHEMBL11215485 0.81 HDAC8 (0.62) HDAC8HDAC6HDAC3HDAC11DEGS1
SCHEMBL29034045 0.80 EPHX1 (0.62) RORC
SCHEMBL8742405 0.80 HDAC8 (0.53) HDAC8HDAC6HDAC3HDAC11DEGS1
SCHEMBL3822159 0.80 SLC18A3 (0.67) HDAC8HDAC6HDAC3HDAC11DEGS1
SCHEMBL3428205 0.80 HDAC3 (0.53) HDAC8HDAC6HDAC3HDAC11DEGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4253536-A2 DIFFUSION RESISTANCE LAYER FOR ANALYTE SENSORS DexCom, Inc. (US) 2023-10-04 EP disclosed
EP-3397163-B1 DIFFUSION RESISTANCE LAYER FOR ANALYTE SENSORS DEXCOM INC (US) 2023-09-13 EP disclosed
EP-3397162-B1 MEMBRANE LAYERS FOR ANALYTE SENSORS DEXCOM INC (US) 2023-09-06 EP disclosed
WO-2017117565-A1 MEMBRANE LAYERS FOR ANALYTE SENSORS DEXCOM, INC. (US) 2017-07-06 WO disclosed
WO-2017117469-A1 DIFFUSION RESISTANCE LAYER FOR ANALYTE SENSORS DEXCOM, INC. (US) 2017-07-06 WO disclosed