⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20468593 | 0.79 | — | — | |
| SCHEMBL23347477 | 0.77 | — | — | |
| SCHEMBL23110249 | 0.76 | BRS3 (0.31) | — | |
| SCHEMBL19101474 | 0.74 | HPGD (0.43) | — | |
| SCHEMBL20021615 | 0.72 | — | — | |
| SCHEMBL21727183 | 0.70 | CYP19A1 (0.33) | — | |
| SCHEMBL12012896 | 0.69 | — | — | |
| SCHEMBL680605 | 0.68 | — | — | |
| SCHEMBL7179426 | 0.68 | TAAR1 (0.34) | — | |
| SCHEMBL12993678 | 0.68 | SHBG (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230201178-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | KREOS CAPITAL VII (UK) LIMITED (GB) | 2023-06-29 | — | — | US | disclosed |
| US-10729681-B2 | Prolyl hydroxylase inhibitors and methods of use | AKEBIA THERAPEUTICS, INC. (US) | 2020-08-04 | — | — | US | disclosed |
| US-20190192494-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | KREOS CAPITAL VII (UK) LIMITED (GB) | 2019-06-27 | — | — | US | disclosed |
| US-9795594-B2 | Human protein tyrosine phosphatase inhibitors and methods of use | AERPIO THERAPEUTICS, INC. (US) | 2017-10-24 | — | — | US | disclosed |
| US-20170189387-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | WARNER CHILCOTT COMPANY, LLC (PR) | 2017-07-06 | — | — | US | disclosed |