Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 13/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 13/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19086006 | 0.93 | KDM4E (0.38) | KMT2AKDM4EMEN1SMN1; SMN2RXFP1 | |
| SCHEMBL19086007 | 0.93 | PRMT5 (0.40) | KMT2AKDM4EMEN1SMN1; SMN2RXFP1 | |
| SCHEMBL19086194 | 0.93 | PRMT5 (0.43) | KMT2APRMT5WDR77HCRTR2HCRTR1 | |
| SCHEMBL19086211 | 0.92 | PRMT5 (0.42) | KMT2AKDM4ESMN1; SMN2PRMT5WDR77 | |
| SCHEMBL19086016 | 0.91 | PRMT5 (0.42) | KMT2AKDM4EPRMT5WDR77HCRTR2 | |
| SCHEMBL19086981 | 0.88 | PRMT5 (0.38) | KDM4EPRMT5WDR77 | |
| SCHEMBL19086207 | 0.88 | PRMT5 (0.36) | KDM4EPRMT5WDR77HCRTR2HCRTR1 | |
| SCHEMBL19087006 | 0.88 | PRMT5 (0.38) | PRMT5WDR77HCRTR2HCRTR1 | |
| SCHEMBL19086335 | 0.88 | HDAC6 (0.39) | KMT2APRMT5WDR77HCRTR2 | |
| SCHEMBL19086233 | 0.87 | KMT2A (0.50) | KMT2APRMT5WDR77HCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114275-A1 | COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME | 成都先导药物开发有限公司 | 2017-07-06 | — | — | WO | disclosed |