Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19086007 | 0.91 | PRMT5 (0.40) | PRMT5WDR77MAPTHCRTR2HPGD | |
| SCHEMBL19086009 | 0.91 | KMT2A (0.42) | PRMT5WDR77HCRTR2KDM4EKMT2A | |
| SCHEMBL19086211 | 0.90 | PRMT5 (0.42) | PRMT5WDR77NAMPTMAPTHCRTR2 | |
| SCHEMBL19086232 | 0.88 | EPHX2 (0.43) | PRMT5WDR77HCRTR2MMP13HCRTR1 | |
| SCHEMBL19086006 | 0.87 | KDM4E (0.38) | PRMT5WDR77ALDH1A1KDM4ELMNA | |
| SCHEMBL19086194 | 0.85 | PRMT5 (0.43) | PRMT5WDR77HCRTR2KMT2AHCRTR1 | |
| SCHEMBL19086207 | 0.85 | PRMT5 (0.36) | PRMT5WDR77HCRTR2ALDH1A1KDM4E | |
| SCHEMBL19086981 | 0.84 | PRMT5 (0.38) | PRMT5WDR77ALDH1A1KDM4ELMNA | |
| SCHEMBL19087006 | 0.83 | PRMT5 (0.38) | PRMT5WDR77HCRTR2HCRTR1 | |
| SCHEMBL19086335 | 0.83 | HDAC6 (0.39) | PRMT5WDR77NAMPTHCRTR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114275-A1 | COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME | 成都先导药物开发有限公司 | 2017-07-06 | — | — | WO | disclosed |