SCHEMBL19086006 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	KDM4E	B2RXH2	2/20	0.38

▸	ALDH1A1	P00352	2/20	0.38

▸	PRMT5	O14744	14/20	0.37

▸	WDR77	Q9BQA1	14/20	0.37

▸	MEN1	O00255	1/20	0.36

▸	KMT2A	Q03164	1/20	0.36

▸	SMN1; SMN2	Q16637	1/20	0.36

▸	RXFP1	Q9HBX9	1/20	0.36

▸	LNPEP	Q9UIQ6	1/20	0.36

▸	LMNA	P02545	1/20	0.36

▸	HDAC6	Q9UBN7	1/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19086009	0.93	KMT2A (0.42)	KDM4EPRMT5WDR77MEN1KMT2A
SCHEMBL19086007	0.89	PRMT5 (0.40)	KDM4EALDH1A1PRMT5WDR77MEN1
SCHEMBL19086211	0.89	PRMT5 (0.42)	KDM4EALDH1A1PRMT5WDR77KMT2A
SCHEMBL19086207	0.87	PRMT5 (0.36)	KDM4EALDH1A1PRMT5WDR77LMNA
SCHEMBL19086981	0.87	PRMT5 (0.38)	KDM4EALDH1A1PRMT5WDR77LMNA
SCHEMBL19086016	0.87	PRMT5 (0.42)	KDM4EALDH1A1PRMT5WDR77KMT2A
SCHEMBL19087006	0.87	PRMT5 (0.38)	PRMT5WDR77HDAC6
SCHEMBL19086335	0.87	HDAC6 (0.39)	PRMT5WDR77KMT2AHDAC6
SCHEMBL19086232	0.86	EPHX2 (0.43)	PRMT5WDR77
SCHEMBL19086194	0.86	PRMT5 (0.43)	PRMT5WDR77KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017114275-A1	COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME	成都先导药物开发有限公司	2017-07-06	—	—	WO	disclosed