⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28480300 | 0.86 | ALDH1A1 (0.41) | — | |
| SCHEMBL9505377 | 0.82 | CYP3A4 (0.35) | — | |
| SCHEMBL12475877 | 0.74 | POLB (0.38) | — | |
| SCHEMBL9565229 | 0.71 | ALDH1A1 (0.37) | — | |
| SCHEMBL8664810 | 0.70 | ADRA1D (0.42) | — | |
| SCHEMBL4081505 | 0.67 | CYP3A4 (0.46) | — | |
| SCHEMBL4595249 | 0.67 | MAPT (0.35) | — | |
| SCHEMBL14931781 | 0.67 | — | — | |
| SCHEMBL10501263 | 0.66 | — | — | |
| SCHEMBL4509613 | 0.64 | CYP3A4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110938076-B | Pyrrolopyrimidines as TLR7 agonists | 正大天晴药业集团股份有限公司 | 2021-08-10 | — | — | CN | disclosed |
| CN-112898308-A | Pyrrolopyrimidines as TLR7 agonists | 正大天晴药业集团股份有限公司 | 2021-06-04 | — | — | CN | disclosed |
| EP-3190113-B1 | PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2021-05-19 | — | — | EP | disclosed |
| CN-110759916-B | Pyrrolopyrimidines as TLR7 agonists | 正大天晴药业集团股份有限公司 | 2021-02-19 | — | — | CN | disclosed |
| CN-110938076-A | Pyrrolopyrimidines as TLR7 agonists | 正大天晴药业集团股份有限公司 | 2020-03-31 | — | — | CN | disclosed |
| US-10555949-B2 | Pyrrolopyrimidine compounds used as TLR7 agonist | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2020-02-11 | — | — | US | disclosed |
| CN-110759916-A | Pyrrolopyrimidines as TLR7 agonists | 正大天晴药业集团股份有限公司 | 2020-02-07 | — | — | CN | disclosed |
| CN-109572203-A | Recording method and recording device | 精工爱普生株式会社 | 2019-04-05 | — | — | CN | disclosed |
| US-20180303832-A1 | PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-10-25 | — | — | US | disclosed |
| US-9962388-B2 | Pyrrolopyrimidine compounds used as TLR7 agonist | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-05-08 | — | — | US | disclosed |
| US-20170273983-A1 | PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2017-09-28 | — | — | US | disclosed |
| EP-3190113-A1 | PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST | Chai Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2017-07-12 | — | — | EP | disclosed |