SCHEMBL19086892

SCHEMBL19086892

Nc1ccn(Cc2ccc(F)cc2F)n1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.67
MEN1 O00255 1/20 0.67
KMT2A Q03164 1/20 0.67
L3MBTL1 Q9Y468 2/20 0.59
HDAC1 Q13547 2/20 0.49
HDAC7 Q8WUI4 1/20 0.49
KDM4E B2RXH2 2/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
TDP1 Q9NUW8 1/20 0.44
IDO1 P14902 2/20 0.42
AGXT P21549 2/20 0.42
MPO P05164 1/20 0.39
KLKB1 P03952 1/20 0.39
ADORA2A P29274 2/20 0.36
ADORA3 P0DMS8 1/20 0.36
ADORA2B P29275 1/20 0.36
ADORA1 P30542 1/20 0.36
MAPT P10636 1/20 0.36
PKM P14618 1/20 0.36
ADRA2B P18089 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19086959 0.87 ALDH1A1 (0.67) ALDH1A1MEN1KMT2AL3MBTL1HDAC1
SCHEMBL3440031 0.84 L3MBTL1 (0.56) ALDH1A1MEN1KMT2AL3MBTL1KDM4E
SCHEMBL27925763 0.84 HDAC1 (0.49) ALDH1A1MEN1KMT2AL3MBTL1HDAC1
SCHEMBL3440030 0.80 ALDH1A1 (1.00) ALDH1A1MEN1KMT2AL3MBTL1SMN1; SMN2
SCHEMBL3440024 0.79 L3MBTL1 (0.54) ALDH1A1MEN1KMT2AL3MBTL1HDAC1
SCHEMBL2271144 0.76 L3MBTL1 (0.66) ALDH1A1MEN1KMT2AL3MBTL1HDAC1
SCHEMBL12468488 0.75 L3MBTL1 (0.52) ALDH1A1MEN1KMT2AL3MBTL1HDAC1
SCHEMBL28116300 0.75 HDAC1 (0.47) ALDH1A1MEN1KMT2AL3MBTL1HDAC1
SCHEMBL2269162 0.74 L3MBTL1 (1.00) ALDH1A1MEN1KMT2AL3MBTL1SMN1; SMN2
SCHEMBL3440025 0.74 ALDH1A1 (0.77) ALDH1A1MEN1KMT2AL3MBTL1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2999338-B1 KNOWN AND NOVEL HETEROCYCLIC COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2017-07-12 EP disclosed