Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 7/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19087013 | 0.84 | KDM1A (0.46) | KDM1APRMT5WDR77CCNCCDK8 | |
| SCHEMBL19085990 | 0.84 | BRAF (0.40) | HCRTR2KMT2APRMT5WDR77HCRTR1 | |
| SCHEMBL19086005 | 0.83 | EGFR (0.42) | HCRTR2KMT2APRMT5WDR77CDK8 | |
| SCHEMBL19086011 | 0.83 | KDM1A (0.43) | HCRTR2KMT2AKDM1APRMT5WDR77 | |
| SCHEMBL19086348 | 0.81 | KDM1A (0.41) | HCRTR2KMT2AKDM1APRMT5WDR77 | |
| SCHEMBL19085981 | 0.79 | TRPV1 (0.41) | HCRTR2KMT2APRMT5WDR77SMO | |
| SCHEMBL19085999 | 0.79 | TRPV1 (0.41) | HCRTR2KMT2APRMT5WDR77SMO | |
| SCHEMBL19086009 | 0.79 | KMT2A (0.42) | HCRTR2KMT2APRMT5WDR77HCRTR1 | |
| SCHEMBL19086335 | 0.79 | HDAC6 (0.39) | HCRTR2KMT2APRMT5WDR77HDAC6 | |
| SCHEMBL19086194 | 0.78 | PRMT5 (0.43) | HCRTR2KMT2APRMT5WDR77HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114275-A1 | COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME | 成都先导药物开发有限公司 | 2017-07-06 | — | — | WO | disclosed |