⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8261115 | 0.78 | QDPR (0.49) | — | |
| SCHEMBL14197793 | 0.78 | NOTUM (0.43) | — | |
| SCHEMBL17308184 | 0.77 | CYP2C9 (0.36) | — | |
| SCHEMBL24842475 | 0.77 | NAMPT (0.37) | — | |
| SCHEMBL22142573 | 0.75 | NOTUM (0.41) | — | |
| SCHEMBL18136435 | 0.75 | HPGD (0.41) | — | |
| SCHEMBL1257642 | 0.72 | USP2 (0.43) | — | |
| SCHEMBL13900837 | 0.72 | NOTUM (0.39) | — | |
| SCHEMBL18269036 | 0.72 | NOTUM (0.39) | — | |
| SCHEMBL8163530 | 0.69 | ALDH1A1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017120194-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION (US) | 2017-07-13 | — | — | WO | disclosed |
| US-20170190689-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION | 2017-07-06 | — | — | US | disclosed |