Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.63 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.63 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MLYCD | O95822 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 3/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19087022 | 0.85 | GRM5 (0.67) | SCN10AKCNH2MEN1KMT2ACYP2C9 | |
| SCHEMBL13719442 | 0.84 | SCN10A (0.67) | SCN10AKCNH2CYP11B1CYP11B2SCN2A | |
| SCHEMBL19117103 | 0.83 | CYP11B1 (0.59) | SCN10AKCNH2CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL19087054 | 0.83 | CYP11B1 (0.59) | SCN10AKCNH2CYP11B1CYP11B2SCN2A | |
| SCHEMBL29151266 | 0.81 | LMNA (0.57) | SCN10AALDH1A1PKMMEN1NPC1 | |
| SCHEMBL30354974 | 0.81 | LMNA (0.57) | SCN10AALDH1A1PKMMEN1NPC1 | |
| SCHEMBL19087168 | 0.81 | SCN10A (0.61) | SCN10ACYP11B1CYP11B2SCN2AMEN1 | |
| SCHEMBL19087072 | 0.81 | BCAT2 (0.63) | MEN1NPC1RAB9AKMT2AMAPT | |
| SCHEMBL259705 | 0.80 | MEN1 (0.65) | SCN10AKCNH2CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL24130057 | 0.80 | KCNJ11 (0.47) | SCN10AKCNH2CYP11B1CYP11B2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3792256-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | Incyte Corporation (US) | 2021-03-17 | — | — | EP | disclosed |
| EP-3400221-B1 | PYRAZOL / IMIDAZOL SUBSTITUTED PYRIDINES AS PI3K-GAMMA INHIBITORS | INCYTE CORP (US) | 2020-08-26 | — | — | EP | disclosed |
| WO-2017120194-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION (US) | 2017-07-13 | — | — | WO | disclosed |
| US-20170190689-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190689-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | PIK3CG, PIK3CD, PIK3CB | SCN10A 1390/4885KCNH2 2582/4885CYP11B1 1760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.