Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 5/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TAS2R8 | Q9NYW2 | 2/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18232748 | 0.83 | CREBBP (0.60) | CREBBPALKITKAURKAKLKB1 | |
| SCHEMBL19077891 | 0.83 | CYP19A1 (0.51) | ITKKLKB1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL19116683 | 0.82 | CREBBP (0.59) | CREBBPALKITKAURKAKLKB1 | |
| SCHEMBL14699090 | 0.81 | MEN1 (0.59) | CREBBPALKITKAURKAKLKB1 | |
| SCHEMBL19077889 | 0.80 | ALDH1A1 (0.49) | CYP11B1CYP11B2TAS2R8ERCC5ALDH1A1 | |
| SCHEMBL25583710 | 0.79 | SCD (0.56) | ALKKLKB1SCDMEN1KMT2A | |
| SCHEMBL19077887 | 0.79 | KDM4E (0.51) | ALKITKKLKB1CYP11B1CYP11B2 | |
| SCHEMBL10141551 | 0.78 | L3MBTL1 (0.59) | CREBBPCYP19A1ALDH1A1SCDL3MBTL1 | |
| SCHEMBL15652083 | 0.77 | CREBBP (0.57) | CREBBPALKITKAURKAKLKB1 | |
| SCHEMBL25583760 | 0.76 | CACNA1H (0.53) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352340-B2 | Pyridine and pyridimine compounds as PI3K-gamma inhibitors | INCYTE CORPORATION (US) | 2022-06-07 | — | — | US | disclosed |
| US-20170190689-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352340-B2 | Pyridine and pyridimine compounds as PI3K-gamma inhibitors | PIK3CG, PIK3CD, PIK3CB | CREBBP 1949/4885ALK 1055/4885ITK 612/4885 |
| US-20170190689-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | PIK3CG, PIK3CD, PIK3CB | CREBBP 1949/4885ALK 1055/4885ITK 612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.