Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.52 |
| ▸ | TAS2R8 | Q9NYW2 | 2/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19086984 | 0.85 | CD74 (0.57) | POLBTDP1L3MBTL1KDM4EKLKB1 | |
| SCHEMBL19116359 | 0.85 | TDP1 (0.70) | POLBTDP1L3MBTL1HTTKDM4E | |
| SCHEMBL27364039 | 0.85 | L3MBTL1 (0.70) | POLBTDP1L3MBTL1HTTKDM4E | |
| SCHEMBL15601844 | 0.84 | POLB (0.52) | POLBTDP1L3MBTL1HTTKDM4E | |
| SCHEMBL15601876 | 0.84 | KLKB1 (0.58) | POLBTDP1L3MBTL1KDM4EKLKB1 | |
| SCHEMBL19087148 | 0.84 | POLB (0.68) | POLBTDP1L3MBTL1HTTKDM4E | |
| SCHEMBL13736854 | 0.83 | POLB (0.71) | POLBTDP1L3MBTL1HTTKDM4E | |
| SCHEMBL13851465 | 0.83 | TDP1 (1.00) | POLBTDP1L3MBTL1HTTKDM4E | |
| SCHEMBL15154988 | 0.83 | L3MBTL1 (0.60) | POLBTDP1L3MBTL1HTTKDM4E | |
| SCHEMBL27571041 | 0.83 | POLB (0.71) | POLBTDP1L3MBTL1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3792256-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | Incyte Corporation (US) | 2021-03-17 | — | — | EP | disclosed |
| EP-3400221-B1 | PYRAZOL / IMIDAZOL SUBSTITUTED PYRIDINES AS PI3K-GAMMA INHIBITORS | INCYTE CORP (US) | 2020-08-26 | — | — | EP | disclosed |
| US-20170190689-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190689-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | PIK3CG, PIK3CD, PIK3CB | POLB 630/4885TDP1 554/4885L3MBTL1 4436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.